Saturday, August 23, 2014

FDA Approves Human Trials, Islet Replacement

FDA approves clinical trials for "..... type 1 diabetes (T1D) encapsulated cell replacement therapy called VC-01™. The company plans to immediately initiate the first ever clinical evaluation of a stem cell-derived islet replacement therapy for the treatment of people with T1D. The trial will enroll approximately 40 people at multiple clinical sites."

http://jdrf.org/blog/2014/jdrf-partner-viacyte-to-immediately-initiate-type-1-diabetes-clinical-trial/

Monday, August 18, 2014

I Thought I Was Cured!!! HaHa!


On Saturday I forgot to bolus at breakfast. Two hours later I discovered my mistake, and thought I would have a high. I had a meal of 31 carbs, and should have bolused 3 units. My test before breakfast was 94, and two hours later it was 89, so I still did not bolus. My pump showed that I had not bolused, and there was no insulin on board. Seeing my BG drop without a bolus was very strange, and it has never happened before. I did not need insulin, and I thought I might do the Snoopy dance, climb up on the roof, and yell "I'm cured"!!! I restrained myself, and waited for lunch.

Before lunch my test was 82, and I bolused 4.2 units for a 42 carb meal. Two hours after lunch my test was 72. I had a snack at 3 PM, The test was 110 before the snack, and 69 two hours after the snack. Sunday was very similar, but I did remember to bolus at every meal. Before breakfast my test was 88, and I bolused 3 units for a 35 carb meal. Two hours later my test was 43. I guess I should not have bolused at that breakfast either.

I have no explanation for any of these strange happenings, but I am testing frequently. Today (Monday) testing is much more normal, so I guess my "cure" was only temporary. HA!

The Joslin Medalist Study has shown that there are many long term medalists who still produce some insulin after 50+ years of type 1. One lady does occasionally produce enough insulin that she reduces her insulin dosages a lot, and sometimes does not need any insulin at all. These episodes are temporary for her, and she eventually needs full dosages again. I doubt that I would suddenly have some insulin production after 68 years of type 1, but these strange occurrences certainly do make me wonder!!!

Wednesday, August 13, 2014

Seizures With Diabetes

In the Facebook Joslin medalist group someone asked if any of us had experienced seizures due to low blood sugar. Every medalist had been type 1 for at least 50 years, and most of the 53 replies given indicated there had been no seizures. Only a few said they had experienced seizures. 

I always thought that a low that caused unconsciousness, with difficulty in being revived, was a seizure. Some medalists were saying that unconsciousness with a low is not a seizure, even if glucagon or a trip to the ER is involved. I began thinking I did not know the true definition of "seizure".

How do you define a seizure? I found the following definition of seizure on Google:

"Seizure: Uncontrolled electrical activity in the brain, which may produce a physical convulsion, minor physical signs, thought disturbances, or a combination of symptoms.The type of symptoms and seizures depend on where the abnormal electrical activity takes place in the brain, what its cause is, and such factors as the patient's age and general state of health.

Seizures can be caused by head injuries, brain tumors, lead poisoning, maldevelopment of the brain, genetic and infectious illnesses, and fevers. In fully half of the patients with seizures, no cause can yet be found."

One medalist said she had many seizures when she was very young. She fought and bit her tongue, and lost part of her tongue with the biting. A few medalists have had seizures with terrible convulsions. Most medalists have not had seizures in light of the definition given.

During my first 60 years with type 1, I had at least 200 episodes with unconsciousness and difficulty in being revived, but I never had convulsions or needed to be restrained, so I conclude that I have never had a seizure. After starting pumping in 2007, I have not needed assistance with a low.

Have any of you reading this post had seizures? If so, were they long ago, or do you still have them? This may be a very personal question, so I understand if you do not want to reply.

Wednesday, August 6, 2014

Interviewed by Miracles of Hope

I was interviewed in a telephone conference call on the Miracles Of Hope website. You can find this interview and other interviews on their site, and on Facebook. The sound is not very good in spots, but here is the link:

https://www.freeconferencecall.com/w...tionId=3297619

Sunday, July 13, 2014

Repeated Hypoglycemia May Not Cause Brain Damage

Repeated Hypoglycemia May Not Cause Brain Damage
One recent study asserts that ".... the brains of type 1 diabetic
patients who suffer repeated episodes of hypoglycemia actually adapt
in a positive manner. The results of the study, published in the May
2014 issue of the Journal of Diabetes Investigation, … suggest that
the brain can increase its usage of alternative energy sources when
glucose is not sufficient, and this adaptive response can be promoted
by repetitive hypoglycemia."
For many years I have suspected this finding to be true. At the
present time I can have a hypo as low as the 30's gradually sneak up
on me and I do not notice. I have become so accustomed to these lows,
about three or four per month, that I can function very well, and do
not need help with them. If My BG drops faster I can feel them when I
am in the low 70's and have blurred vision. With a slow drop my body
and brain adjusts so well that I do not notice until I am very low. My
endo insists that I am having damage from these lows, but I do not
believe that. I had so many seizures from age six into adulthood, and
my mom, and eventually my wife, had to revive me with great
difficulty. I went on to six years in college and became a math
professor. My brain was not damaged, not at all.